Ansamitocin P-3

Research use only, not for human use.

A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM).

A microtubule depolymerizing agent that can be isolated from culture broths of certain Gram-positive bacteria; binds tubulin (Kd=1.3 uM), depolymerizes microtubules in both interphase and mitosis, and perturbs chromosome segregation; inhibits the growth of cancer cells in culture and significantly suppresses the growth of several cancer tumors in mice.

Maytansinol butyrate

Antibody Drug Conjugates (ADC)

ADC Cytotoxin

microtubule

Cancer

——

66547-09-9

635.14

C32H43ClN2O9

>98% (HPLC)

10 mM in DMSO

C[C@@H]1[C@@H]2C[C@]([C@@H](/C=C/C=C(/CC3=CC(=C(C(=C3)OC)Cl)N(C(=O)C[C@@H]([C@]4([C@H]1O4)C)OC(=O)C(C)C)C)\C)OC)(NC(=O)O2)O

Maytansine, 3-O-de[2-(acetylmethylamino)-1-oxopropyl]-3-O-(1-oxobutyl)-

(-20℃)

With Ice Pack

≥ 2 years